coadministration 同时服用
- For fluoxetine and paroxetine, dosage cutting is needed in case of coadministration with CYP2D6 substrates.
与治疗窗较窄的CYP2D 6底物合用时,应注意帕罗西汀和氟西汀的剂量调整。 - Meanwhile, many drugs can influence the activity of CYP2D6 by competitive inhibition or induction, which is easy to cause interaction in coadministration.
而且CYP2D6能被多种药物竞争性抑制和诱导,药物联用时易产生相互作用。 - Coadministration of other known cytochrome P 450 isoenzyme 3A4 inducers (eg, phenytoin and phenobarbital) may lead to similar decreases in risperidone levels and loss of therapeutic effect.
共同服用其他已知的细胞色素P450同工酶3A4(苯妥英和镇静安眠剂)可能导致相似的利培酮水平的降低并失去治疗效果。
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