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 coadministration 添加此单词到默认生词本
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  1. For fluoxetine and paroxetine, dosage cutting is needed in case of coadministration with CYP2D6 substrates.
    与治疗窗较窄的CYP2D 6底物合用时,应注意帕罗西汀和氟西汀的剂量调整。
  2. Meanwhile, many drugs can influence the activity of CYP2D6 by competitive inhibition or induction, which is easy to cause interaction in coadministration.
    而且CYP2D6能被多种药物竞争性抑制和诱导,药物联用时易产生相互作用。
  3. Coadministration of other known cytochrome P 450 isoenzyme 3A4 inducers (eg, phenytoin and phenobarbital) may lead to similar decreases in risperidone levels and loss of therapeutic effect.
    共同服用其他已知的细胞色素P450同工酶3A4(苯妥英和镇静安眠剂)可能导致相似的利培酮水平的降低并失去治疗效果。



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