a chronic progressive disease characterized by chronic fatigue and muscular weakness (especially in the face and neck); caused by a deficiency of acetylcholine at the neuromuscular junctions
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any muscular weakness
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Smith suffers from myasthenia gravis, a sometimes fatal muscle disease that is among the 40 targeted by the MDA.
He also helped develop the diagnostic test for myasthenia gravis with Dr. George Gammon in the late 1930s.