Kaposis sarcoma 卡波济氏肉瘤
- The patients each had been newly diagnosed as having Kaposi's sarcoma, a skin cancer that afflicts AIDS patients.
- Research from the National Cancer Institute suggests that Kaposi's sarcoma, an AIDS-linked tumor, is provoked by a previously unknown growth factor and may not be a true malignancy at all.
- When SP-PG was tested in immune-deficient mice that were injected with Kaposi's sarcoma cells, the drug seemed to prevent both the growth of blood vessels and the leakage of fluid from existing blood vessels.
- He reported a provocative experiment in which human Kaposi's cells were transplanted onto a mouse.
- For Mike, an accountant, three years of chemotherapy kept the skin sores of Kaposi's sarcoma at bay.
- Thus it won't be approved initially for other AIDS patients, such as those suffering from Kaposi's sarcoma in whom AZT's benefits have yet to be proven, or for less-ill AIDS patients in whom its side effects would be intolerable.
- Others have evidence indicating Kaposi's sarcoma may be caused by another virus, not the AIDS virus, but Gallo's work questions that theory.
- They said Crawford's skin lesions weren't the rare AIDS-related Kaposi's sarcoma; they were cat scratch fever.
- Dr. Gallo also proposed trying to harness a protein called oncostatin as possible weapon against Kaposi's sarcoma, and taking aim against an enzyme called ribonucleotide reductase as another target for an anti-viral drug against AIDS.
- For example, it costs more to care for patients with one AIDS manifestation, pneumocystis carinii pneumonia, than it does to treat patients with Kaposi's sarcoma, an AIDS-related cancer.
- The Kaposi's sarcoma cells in turn release "a cascade" of other protein-based growth factors, Dr. Gallo said.
- Kaposi's can cause death when it attacks the lungs or other vital organs, although most AIDS patients die of other causes.
- His report dealt with a study involving Kaposi's sarcoma developed in mice that were genetically engineered to contain an AIDS virus gene called tat.
- The finding suggests the HPV virus may be the cause of Kaposi's sarcoma, presenting doctors with a new direction for trying to treat or prevent the cancer, the researchers said.
- Current treatment controls Kaposi's but does not cure it, and the disease itself only rarely kills AIDS patients, said Alvin Friedman-Kien, professor of dermatology and microbiology at the New York University Medical Center.
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