英德
有道
百度
谷歌
图片
维基
百科
脆性位点 [cuì xìng wèi diǎn]
[遗] fragile site
- 染色体脆性位点的的分布两组基本一致。
But the distribution of chromosome fragile site proved to be coincident in both groups. - 因而在脆性位点如何区分乘客基因缺失还是肿瘤抑制基因的驱动缺失具有很大的挑战性。
Therefore the challenge is how to distinguish between the passenger deletions over fragile sites and the driver deletions over tumour suppressor genes. - 有报道指出位于脆性位点的基因由于对DNA双链断裂及错误修复较为敏感，因而可能在错配修复缺陷肿瘤中成为损伤的靶目标。
It is reported that the gene at fragile site is susceptible to DNA double strand breaks and disrepair, so it could be the target of damage in mismatch repair deficient tumors.
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